Wheeling Hospital in West Virginia confirms the death of 43-year-old Richard Hughes of Bellaire, Ohio.
The man’s girlfriend called the paramedics on Sunday after she found him unconscious.
The man was wedged in his recliner where his skin was fused into the chair from prolonged sitting.
Rescuers had to cut a hole in the wall of his house to get him out as they could not immediately remove him from the chair.
Fire-crews carried the 43-year-old man out of his house. He was rushed to Wheeling Hospital in a critical condition but later died, officers said.
The health officials reported that they found the man sitting in his own faeces and urine covered in maggots at the house on Sunday.
The girlfriend admitted that she had been feeding him by hand since he became too big to get up.
He insisted that his girlfriend feed him food and soft drinks.
Sources told the local Bellaire TV channel that the man insisted on eating, drinking and sleeping in the chair.
Hughes’ friends said that he had been complaining that the arthritis in his knees were too painful every time he tried to move.
One friend said: “I tried to suggest him going to the hospital and getting his legs checked out, but he wouldn’t do it. He said he didn’t like doctors. So you can’t force somebody to do something that they don’t want to do.”
Health officials said three people were living in the house.
One officer said it was the worst thing he had ever responded to.
Another health official said after coming into contact with the obese man he’d been forced to throw his uniform away.
City health official Jim Chase said, “The chair was very filthy, a lot of odour to it. Going in the house, the house was not clean. The living room where the man lived in his chair was very filthy, very deplorable. It’s unbelievable that somebody lives in conditions like that.”
Landlord, Lou Ann Bennett says that 157-kilogram man used to be active until his knees started hurting, then he got in the chair and wouldn’t move around.
She said she hadn’t noticed his appalling condition because he’d been hiding himself under a blanket whenever she stopped by.
She says he needs to be left to “rest in peace”.